- Home
- ASDP Case Study Submission Gallery
- A 30-year-old woman presented for evaluation of a painless coin-sized lesion under the tongue of several months’ duration.
Interactive Case Study - 04- April 2024


Fellegara G, Bisceglia M. Intraneural schwannoma. Int J Surg Pathol. 2008 Jan;16(1):57–8.
Reed RJ, Fine RM, Meltzer HD. Palisaded, encapsulated neuromas of the skin. Arch Dermatol. 1972 Dec;106(6):865–70.
Argenyi ZB, Santa Cruz D, Bromley C. Comparative light-microscopic and immunohistochemical study of traumatic and palisaded encapsulated neuromas of the skin. Am J Dermatopathol. 1992 Dec;14(6):504–10
Wasserteil V, Bruce S, Riccardi VM. Non-von Recklinghausen’s neurofibromatosis presenting as hemifacial neurofibromas and contralateral cafe au lait spots. J Am Acad Dermatol. 1987 May;16(5):1090–6.
Barbarot S, Nicol C, Volteau C, Le Forestier D, N’Guyen JM, Mansat E, et al. Cutaneous lesions in neurofibromatosis 1: confused terminology. Br J Dermatol. 2007 Jul;157(1):183–4.
Bakshi SS. Plexiform neurofibroma. Cleve Clin J Med. 2016 Nov;83(11):792–792.
Tchernev G, Chokoeva AA, Patterson JW, Bakardzhiev I, Wollina U, Tana C. Plexiform Neurofibroma: A Case Report. Medicine (Baltimore). 2016 Feb;95(6):e2663.
Woodruff JM, Scheithauer BW, Kurtkaya-Yapcer Ö, Raffel C, Amr SS, LaQuaglia MP, et al. Congenital and Childhood Plexiform (Multinodular) Cellular Schwannoma: A Troublesome Mimic of Malignant Peripheral Nerve Sheath Tumor. Am J Surg Pathol. 2003 Oct;27(10):1321–9.
Kao GF, Laskin WB, Olsen TG. Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases. Mod Pathol Off J U S Can Acad Pathol Inc. 1989 Jan;2(1):20–6.
Clausen L, Stein A, Grønbæk-Thygesen M, Nygaard L, Søltoft CL, Nielsen SV, et al. Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation. Henske E, editor. PLOS Genet. 2020 Nov 2;16(11):e1009187.
Lim A, Ngeow J. The Skin in Cowden Syndrome. Front Med. 2021 Jun 10;8:658842.
Huang W, Chong WS. Facial plexiform neurofibroma: is it truly just skin deep? BMJ Case Rep. 2013 Oct 7;2013:bcr2013200716.
De Luca A, Bottillo I, Dasdia MC, Morella A, Lanari V, Bernardini L, et al. Deletions of NF1 gene and exons detected by multiplex ligation-dependent probe amplification. J Med Genet. 2007 Dec;44(12):800–8.
Miller MB, Tonsgard JH, Soltani K. Late-onset neurofibromatosis in a liver transplant recipient. Int J Dermatol. 2000 May;39(5):376–9.
Person JR, Perry HO. Recent advances in the phakomatises. Int J Dermatol. 1978 Feb;17(1):1–13.
Kissil JL, Wilker EW, Johnson KC, Eckman MS, Yaffe MB, Jacks T. Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1. Mol Cell. 2003 Oct;12(4):841–9.
Randle SC. Tuberous Sclerosis Complex: A Review. Pediatr Ann [Internet]. 1;46(4). doi:10.3928/19382359-20170320-01
Acknowledgements
Author Profiles

Tatsiana Pukhalskaya, MD
University of California San Francisco (UCSF), Department of Dermatopathology and Oral Pathology

Richard C. Jordan DDS, PhD, FRCPath
University of California San Francisco (UCSF), Department of Dermatopathology and Oral Pathology
Dr. Richard Jordan is a Professor of Oral Pathology, Pathology and Radiation Oncology at the University of California, San Francisco. He is a member of the UCSF Dermatopathology and Oral Pathology Service practicing the full scope of head and neck pathology. He is also one of the Directors of the NRG Oncology Biospecimen Bank, an NCI funded program that supports national phase 2 and phase 3 clinical cancer trials. Originally from Toronto Canada, he has resided in the San Francisco Bay area for 25 years.
Question:
A 30-year-old woman presented for evaluation of a painless coin-sized lesion under the tongue of several months’ duration.
Category
Tumors > Neural/Neuroendocrine
Description